CD44 monoclonal antibody, clone MEM-85 (PE)
产品名称: CD44 monoclonal antibody, clone MEM-85 (PE)
英文名称: CD44 monoclonal antibody, clone MEM-85 (PE)
产品编号: MAB4571
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native CD44.
- Immunogen:
- Native purified CD44 from leukocytes of patient suffering from LGL-type leukaemia.
- Host:
- Mouse
- Theoretical MW (kDa):
- 80-95
- Reactivity:
- Human
- Specificity:
- This antibody reacts with both cell surface-expressed and soluble form of CD44 antigen (Phagocyte glycoprotein 1), a 80-95 KDa transmembrane glycoprotein (hyaladherin family) present on the most of cells and tissues (leukocytes, endothelial cells, mesenchymal cells, etc.); it is negative on platelets and hepatocytes.
- Form:
- Liquid
- Conjugation:
- PE
- Isotype:
- IgG2b
- Storage Buffer:
- In PBS (0.2% BSA, 15 mM sodium azide)
- Storage Instruction:
- Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- CD44 regulates cell migration in human colon cancer cells via Lyn kinase and AKT phosphorylation.
Subramaniam V, Vincent IR, Gardner H, Chan E, Dhamko H, Jothy S.Exp Mol Pathol. 2007 Oct;83(2):207-15. Epub 2007 May 13.
- 2.
- Down-regulation of CD44 contributes to the differentiation of HL-60 cells induced by ATRA or HMBA.
Liu J, Bi G, Wen P, Yang W, Ren X, Tang T, Xie C, Dong W, Jiang G.Cell Mol Immunol. 2007 Feb;4(1):59-63.
- 3.
- Metalloprotease and serine protease are involved in cleavage of CD43, CD44, and CD16 from stimulated human granulocytes. Induction of cleavage of L-selectin via CD16.
Bazil V, Strominger JL.J Immunol. 1994 Feb 1;152(3):1314-22.
- Entrez GeneID:
- 960
- Gene Name:
- CD44
- Gene Alias:
- CDW44,CSPG8,ECMR-III,HCELL,IN,LHR,MC56,MDU2,MDU3,MGC10468,MIC4,MUTCH-I,Pgp1
- Gene Description:
- CD44 molecule (Indian blood group)
- Omim ID:
- 107269
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq
- Other Designations:
- CD44 antigen,CD44 antigen (homing function and Indian blood group system),CDW44 antigen,GP90 lymphocyte homing/adhesion receptor,Hermes antigen,antigen gp90 homing receptor,cell adhesion molecule,cell surface glycoprotein CD44,chondroitin sulfate proteogl
- Gene Pathway
- Related Disease
- Arthritis, Rheumatoid
- Breast Neoplasms
- Cardiovascular Diseases
- Cleft Lip
- Cleft Palate
- Craniofacial Abnormalities
- Diabetes Mellitus, Type 2
- Edema
- Genetic Predisposition to Disease
- Head and Neck Neoplasms
- Heart Defects, Congenital
- Hepatitis B
- Kidney Failure, Chronic
- Mouth Abnormalities
- Neoplasm Recurrence, Local
- Neoplasms, Second Primary
- Ovarian Neoplasms