Anti-PTEN Polyclonal Antibody

品牌：solarbio | 货号：K002278P

商品货号：	商品品牌：	规格	基本售价：	选择规格
K002278P-50ul	solarbio	50ul	960.00元
K002278P-100ul	solarbio	100ul	1600.00元

英文名称	Anti-PTEN Polyclonal Antibody
别名	10q23del;BZS;CWS1;DEC;GLM2;MHAM;MMAC1;PTEN1;TEP1
应用	WB IHC IF
稀释比例	WB 1:500-2000. IHC 1:50-100. IF 1:50-200.
交叉反应	Human Mouse Rat Monkey
蛋白分子量	47kDa
Gene ID	5728
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	Recombinant protein of human PTEN
性状	液体
Public Immunogen Range	Recombinant protein of human PTEN
Subcellular Locations	Cytoplasm Nucleus PML body Secreted
Swiss Prot	P60484
克隆类型	Polyclonal Antibody
背景资料	This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.